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Science 19 February 1982:
Vol. 215. no. 4535, pp. 983 - 985
DOI: 10.1126/science.6296998
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Articles

Science, Vol 215, Issue 4535, 983-985
Copyright © 1982 by American Association for the Advancement of Science

articles

Homologous regulation of gonadotropin-releasing hormone receptors in cultured pituitary cells

E Loumaye and KJ Catt

Specific receptors for gonadotropin-releasing hormone (GnRH) in cultured rat pituitary cells were increased by subnanomolar concentrations of GnRH agonists and decreased by high concentrations of these peptides. The antagonist [D-Phe2, Pro3, D-Phe6]GnRH did not alter GnRH binding capacity and blocked the increase in sites induced by GnRH. These findings provide direct evidence for the homologous regulation of GnRH receptors by physiological concentrations of the hypothalamic peptide, an action that could mediate the cyclical and postcastration increases in GnRH receptors and responsiveness of the pituitary gonadotrophs.


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A mathematical model quantifying GnRH-induced LH secretion from gonadotropes.
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Am J Physiol Endocrinol Metab 278, E263-E272
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Transcriptional Regulation of the Gonadotropin-Releasing Hormone Receptor Gene Is Mediated in Part by a Putative Repressor Element and by the Cyclic Adenosine 3',5'-Monophosphate Response Element.
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Endocrinology 140, 3452-3458
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Human Peripheral Blood Mononuclear Cells Express Gonadotropin-Releasing Hormone (GnRH), GnRH Receptor, and Interleukin-2 Receptor {gamma}-Chain Messenger Ribonucleic Acids That Are Regulated by GnRH in Vitro.
H.-F. Chen, E.-B. Jeung, M. Stephenson, and P. C. K. Leung (1999)
J. Clin. Endocrinol. Metab. 84, 743-750
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Differential Effects of Gonadotropin-Releasing Hormone (GnRH) Pulse Frequency on Gonadotropin Subunit and GnRH Receptor Messenger Ribonucleic Acid Levels in Vitro.
U. B. Kaiser, A. Jakubowiak, A. Steinberger, and W. W. Chin (1997)
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Studies of Gonadotropin-Releasing Hormone (GnRH) Action Using GnRH Receptor-Expressing Pituitary Cell Lines.
U. B. Kaiser, P. M. Conn, and W. W. Chin (1997)
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Luteinizing hormone-releasing hormone (LH-RH) antagonist Cetrorelix down-regulates the mRNA expression of pituitary receptors for LH-RH by counteracting the stimulatory effect of endogenous LH-RH.
M. Kovacs, A. V. Schally, B. Csernus, and Z. Rekasi (2001)
PNAS 98, 1829-1834
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