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Science 19 February 1982:
Vol. 215. no. 4535, pp. 981 - 982
DOI: 10.1126/science.6186021
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Articles

Science, Vol 215, Issue 4535, 981-982
Copyright © 1982 by American Association for the Advancement of Science

articles

Linkage analysis of nondeletion hereditary persistence of fetal hemoglobin

JM Old, H Ayyub, WG Wood, JB Clegg, and DJ Weatherall

Nondeletion forms of hereditary persistence of fetal hemoglobin may result from regulatory disorders of globin gene expression. The defects in two such conditions were localized by demonstrating a tight genetic linkage between the disorders and polymorphic restriction endonuclease sites within the beta-like globin gene complex. In one instance, the defect probably occurred outside the region of DNA between the epsilon- and beta-globin genes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Gene Map of Homo sapiens: Status and Prospectus.
V.A. McKusick (1986)
Cold Spring Harb Symp Quant Biol 51, 15-27
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