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Science 5 February 1982:
Vol. 215. no. 4533, pp. 693 - 695
DOI: 10.1126/science.7058334
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Articles

Science, Vol 215, Issue 4533, 693-695
Copyright © 1982 by American Association for the Advancement of Science

articles

Primary changes of membrane currents during retention of associative learning

DL Alkon, I Lederhendler, and JJ Shoukimas

A single identified neuron was repeatedly isolated by axotomy from the central nervous system of the nudibranch mollusk Hermissenda crassicornis. An early voltage-dependent outward K+ current of this neuron was reduced and more rapidly inactivated for animals previously trained with paired but not randomized light and rotation. Since this current change can affect interneuron and motorneuron output via known synaptic pathways, it helps explain a long-lasting behavioral change that shows the defining features of vertebrate associative learning.


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Inhibition of Conditioned Stimulus Pathway Phosphoprotein 24 Expression Blocks the Reduction in A-Type Transient K+ Current Produced by One-Trial In Vitro Conditioning of Hermissenda.
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Protein Kinase A Mediates Voltage-Dependent Facilitation of Ca2+ Current in Presynaptic Hair Cells in Hermissenda crassicornis.
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The Effect of Intensity and Duration on the Light-Induced Sodium and Potassium Currents in the Hermissenda Type B Photoreceptor.
K. T. Blackwell (2002)
J. Neurosci. 22, 4217-4228
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T. Crow and L.-M. Tian (2002)
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PP1 Inhibitors Depolarize Hermissenda Photoreceptors and Reduce K+ Currents.
H. Huang and J. Farley (2001)
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Behavioral and Neural Bases of Noncoincidence Learning in Hermissenda.
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J. Neurosci. 19, 9126-9132
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Memory and long-term potentiation (LTP) dissociated: Normal spatial memory despite CA1 LTP elimination with Kv1.4 antisense.
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Intracellular Correlates of Acquisition and Long-Term Memory of Classical Conditioning in Purkinje Cell Dendrites in Slices of Rabbit Cerebellar Lobule HVI.
B. G. Schreurs, P. A. Gusev, D. Tomsic, D. L. Alkon, and T. Shi (1998)
J. Neurosci. 18, 5498-5507
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Phosphorylation of Mitogen-Activated Protein Kinase by One-Trial and Multi-Trial Classical Conditioning.
T. Crow, J.-J. Xue-Bian, V. Siddiqi, Y. Kang, and J. T. Neary (1998)
J. Neurosci. 18, 3480-3487
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Synaptic Enhancement and Enhanced Excitability in Presynaptic and Postsynaptic Neurons in the Conditioned Stimulus Pathway of Hermissenda.
R. J. Frysztak and T. Crow (1997)
J. Neurosci. 17, 4426-4433
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Reversible antisense inhibition of Shaker-like Kv1.1 potassium channel expression impairs associative memory in mouse and rat.
N. Meiri, C. Ghelardini, G. Tesco, N. Galeotti, D. Dahl, D. Tomsic, S. Cavallaro, A. Quattrone, S. Capaccioli, A. Bartolini, et al. (1997)
PNAS 94, 4430-4434
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Ionic Basis of Learning-Correlated Excitability Changes in Hermissenda Type A Photoreceptors.
J. Farley and Y. Han (1997)
J Neurophysiol 77, 1861-1888
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Memory consolidation in Drosophila operant visual learning..
S Xia, L Liu, C Feng, and A Guo (1997)
Learn. Mem. 4, 205-218
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Isolation of a G protein that is modified by learning and reduces potassium currents in Hermissenda.
T. Nelson, C Collin, and D. Alkon (1990)
Science 247, 1479-1483
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Imaging of memory-specific changes in the distribution of protein kinase C in the hippocampus.
J. Olds, M. Anderson, D. McPhie, L. Staten, and D. Alkon (1989)
Science 245, 866-869
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A spatial-temporal model of cell activation.
D. Alkon and H Rasmussen (1988)
Science 239, 998-1005
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Calcium-mediated reduction of ionic currents: a biophysical memory trace.
D. Alkon (1984)
Science 226, 1037-1045
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Ca2+-dependent protein kinase injection in a photoreceptor mimics biophysical effects of associative learning.
J Acosta-Urquidi, D. Alkon, and J. Neary (1984)
Science 224, 1254-1257
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Membrane changes in a single photoreceptor cause associative learning in Hermissenda.
J Farley, W. Richards, L. Ling, E Liman, and D. Alkon (1983)
Science 221, 1201-1203
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A cellular mechanism of classical conditioning in Aplysia: activity-dependent amplification of presynaptic facilitation.
R. Hawkins, T. Abrams, T. Carew, and E. Kandel (1983)
Science 219, 400-405
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Associative conditioning of single sensory neurons suggests a cellular mechanism for learning.
E. Walters and J. Byrne (1983)
Science 219, 405-408
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Protein kinase injection reduces voltage-dependent potassium currents.
D. Alkon, J Acosta-Urquidi, J Olds, G Kuzma, and J. Neary (1983)
Science 219, 303-306
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Molecular biology of learning: modulation of transmitter release.
E. Kandel and J. Schwartz (1982)
Science 218, 433-443
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