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ArticlesCopyright © 1982 by American Association for the Advancement of Science
Histone proteins in HeLa S3 cells are synthesized in a cell cycle stage specific manner
The synthesis of histone proteins in G1 and S phase HeLa S3 cells was examined by two-dimensional electrophoretic fractionation of nuclear and total cellular proteins. Newly synthesized histones were detected only in S phase cells. Histone messenger RNA sequences, as detected by hybridization with cloned human histone genes, were present in the cytoplasm of S phase but not G1 cells.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)