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Science 5 February 1982:
Vol. 215. no. 4533, pp. 670 - 673
DOI: 10.1126/science.6800034
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Articles

Science, Vol 215, Issue 4533, 670-673
Copyright © 1982 by American Association for the Advancement of Science

articles

Cytoplasmic calcium in the mediation of macula densa tubulo-glomerular feedback responses

PD Bell and LG Navar

Within each nephron of the mammalian kidney, a feedback mechanism operating between the macula densa segment of the distal tubule and the afferent arteriole participates in the regulation of glomerular filtration rate. Retrograde microperfusion studies in rats were conducted to test the hypothesis that activation of macula densa cytoplasmic calcium is involved in the transmission of feedback signals to the vascular elements. Perfusion into distal tubules with a hypotonic solution (70 milliosmolar) elicited moderate decreases in glomerular pressure of 6 +/- 0.8 millimeters of mercury. With the addition of a calcium ionophore (A23187) glomerular pressure decreased by 16 +/- 1.1 millimeters of mercury. When a solution devoid of calcium but containing A23187 was used, the feedback response was inhibited. Thus, cytoplasmic calcium within the receptor cells may participate in the transmission of feedback signals to the contractile cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Purinergic Receptor Signaling at the Basolateral Membrane of Macula Densa Cells.
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J. Am. Soc. Nephrol. 13, 1145-1151
   Abstract »    Full Text »    PDF »
Mechanism by Which Superoxide Potentiates Tubuloglomerular Feedback.
Y. Ren, O. A. Carretero, and J. L. Garvin (2002)
Hypertension 39, 624-628
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Nystatin and valinomycin induce tubuloglomerular feedback.
Y. Ren, H. Yu, H. Wang, O. A. Carretero, and J. L. Garvin (2001)
Am J Physiol Renal Physiol 281, F1102-F1108
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20-HETE and the kidney: resolution of old problems and new beginnings.
J. C. McGiff and J. Quilley (1999)
Am J Physiol Regulatory Integrative Comp Physiol 277, R607-R623
   Abstract »    Full Text »    PDF »
Cytosolic [Ca2+] signaling pathway in macula densa cells.
J. Peti-Peterdi and P. D. Bell (1999)
Am J Physiol Renal Physiol 277, F472-F476
   Abstract »    Full Text »    PDF »
Neuronal Nitric Oxide Synthase-Dependent Afferent Arteriolar Function in Angiotensin II-Induced Hypertension.
A. Ichihara, J. D. Imig, and L. G. Navar (1999)
Hypertension 33, 462-466
   Abstract »    Full Text »    PDF »


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