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Science 22 January 1982:
Vol. 215. no. 4531, pp. 419 - 421
DOI: 10.1126/science.6276976
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Articles

Science, Vol 215, Issue 4531, 419-421
Copyright © 1982 by American Association for the Advancement of Science

articles

Viral receptors on isolated murine and human ependymal cells

M Tardieu and HL Weiner

Viruses that infect ependyma cause ependymitis in humans and hydrocephalus in experimental animals. We report that reovirus type 1 (which induces hydrocephalus in mice) binds to the surface of isolated human and murine ciliated ependymal cells. With the use of recombinant viral clones, the binding property was mapped to the type 1 viral hemagglutinin, which also determines in vivo the affinity of reovirus type 1 for ependyma. Mumps virus, measles virus, parainfluenza type 3, and herpes simplex virus type 1 bind to murine ependyma cells, whereas reovirus type 3, herpes simplex virus type 2, and poliovirus type 2 do not.


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