Science 22 January 1982: Vol. 215. no. 4531, pp. 413 - 415 DOI: 10.1126/science.6120570

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Articles

Dynorphin Immunoreactive Fibers Contact GnRH Neurons in the Human Hypothalamus.

S. K. Dahl, M. Amstalden, L. Coolen, M. Fitzgerald, and M. Lehman (2009)
Reproductive Sciences 16, 781-787
 |  Abstract »  |  PDF »

Retrograde Opioid Signaling Regulates Glutamatergic Transmission in the Hypothalamus.

K. J. Iremonger and J. S. Bains (2009)
J. Neurosci. 29, 7349-7358
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Desipramine Reduces Stress-Activated Dynorphin Expression and CREB Phosphorylation in NAc Tissue.

E. H. Chartoff, M. Papadopoulou, M. L. MacDonald, A. Parsegian, D. Potter, C. Konradi, and W. A. Carlezon Jr. (2009)
Mol. Pharmacol. 75, 704-712
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Dynorphin is a downstream effector of striatal BDNF regulation of ethanol intake.

M. L. Logrip, P. H. Janak, and D. Ron (2008)
FASEB J 22, 2393-2404
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The Dysphoric Component of Stress Is Encoded by Activation of the Dynorphin {kappa}-Opioid System.

B. B. Land, M. R. Bruchas, J. C. Lemos, M. Xu, E. J. Melief, and C. Chavkin (2008)
J. Neurosci. 28, 407-414
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Anxiolytic-Like Effects of {kappa}-Opioid Receptor Antagonists in Models of Unlearned and Learned Fear in Rats.

A. T. Knoll, E. G. Meloni, J. B. Thomas, F. I. Carroll, and W. A. Carlezon Jr. (2007)
J. Pharmacol. Exp. Ther. 323, 838-845
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Long-Acting {kappa} Opioid Antagonists Disrupt Receptor Signaling And Produce Noncompetitive Effects By Activating C-Jun N-Terminal Kinase.

M. R. Bruchas, T. Yang, S. Schreiber, M. DeFino, S. C. Kwan, S. Li, and C. Chavkin (2007)
J. Biol. Chem. 282, 29803-29811
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Endogenous dynorphin in epileptogenesis and epilepsy: anticonvulsant net effect via kappa opioid receptors.

S. Loacker, M. Sayyah, W. Wittmann, H. Herzog, and C. Schwarzer (2007)
Brain 130, 1017-1028
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Sciatic Nerve Ligation-Induced Proliferation of Spinal Cord Astrocytes Is Mediated by {kappa} Opioid Activation of p38 Mitogen-Activated Protein Kinase.

M. Xu, M. R. Bruchas, D. L. Ippolito, L. Gendron, and C. Chavkin (2007)
J. Neurosci. 27, 2570-2581
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The Endomorphin System and Its Evolving Neurophysiological Role.

J. Fichna, A. Janecka, J. Costentin, and J.-C. Do Rego (2007)
Pharmacol. Rev. 59, 88-123
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Kappa Opioid Inhibition of Somatodendritic Dopamine Inhibitory Postsynaptic Currents.

C. P. Ford, M. J. Beckstead, and J. T. Williams (2007)
J Neurophysiol 97, 883-891
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Naltrexone and buprenorphine combination in the treatment of opioid dependence.

G. Gerra, A. Fantoma, and A. Zaimovic (2006)
J Psychopharmacol 20, 806-814
 |  Abstract »  |  PDF »

Kappa Opioid Receptor Activation of p38 MAPK Is GRK3- and Arrestin-dependent in Neurons and Astrocytes.

M. R. Bruchas, T. A. Macey, J. D. Lowe, and C. Chavkin (2006)
J. Biol. Chem. 281, 18081-18089
 |  Abstract »  |  Full Text »  |  PDF »

Functional pharmacology in human brain..

M. Raiteri (2006)
Pharmacol. Rev. 58, 162-193
 |  Abstract »  |  Full Text »  |  PDF »

Possible Involvement of Dynorphin A-(1-17) Release via {micro}1-Opioid Receptors in Spinal Antinociception by Endomorphin-2.

H. Mizoguchi, H. Watanabe, T. Hayashi, W. Sakurada, T. Sawai, T. Fujimura, T. Sakurada, and S. Sakurada (2006)
J. Pharmacol. Exp. Ther. 317, 362-368
 |  Abstract »  |  Full Text »  |  PDF »

The corticotropin-releasing factor receptor-1 pathway mediates the negative affective states of opiate withdrawal.

A. Contarino and F. Papaleo (2005)
PNAS 102, 18649-18654
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Characterization of a Novel Bivalent Morphinan Possessing {kappa} Agonist and {micro} Agonist/Antagonist Properties.

J. L. Mathews, X. Peng, W. Xiong, A. Zhang, S. S. Negus, J. L. Neumeyer, and J. M. Bidlack (2005)
J. Pharmacol. Exp. Ther. 315, 821-827
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Translocation of Dynorphin Neuropeptides across the Plasma Membrane: A PUTATIVE MECHANISM OF SIGNAL TRANSMISSION.

Z. Marinova, V. Vukojevic, S. Surcheva, T. Yakovleva, G. Cebers, N. Pasikova, I. Usynin, L. Hugonin, W. Fang, M. Hallberg, et al. (2005)
J. Biol. Chem. 280, 26360-26370
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Cloning, heterologous expression and pharmacological characterization of a kappa opioid receptor from the brain of the rough-skinned newt, Taricha granulosa.

C S. Bradford, E. A Walthers, B. T Searcy, and F. L Moore (2005)
J. Mol. Endocrinol. 34, 809-823
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Progesterone Increases Dynorphin A Concentrations in Cerebrospinal Fluid and Preprodynorphin Messenger Ribonucleic Acid Levels in a Subset of Dynorphin Neurons in the Sheep.

C. D. Foradori, R. L. Goodman, V. L. Adams, M. Valent, and M. N. Lehman (2005)
Endocrinology 146, 1835-1842
 |  Abstract »  |  Full Text »  |  PDF »

Opioids As Modulators of Cell Death and Survival--Unraveling Mechanisms and Revealing New Indications.

I. Tegeder and G. Geisslinger (2004)
Pharmacol. Rev. 56, 351-369
 |  Abstract »  |  Full Text »  |  PDF »

Cross-talk of opioid peptide receptor and {beta}-adrenergic receptor signalling in the heart.

S. Pepe, O. W.V van den Brink, E. G Lakatta, and R.-P. Xiao (2004)
Cardiovasc Res 63, 414-422
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Evidence That Dynorphin Plays a Major Role in Mediating Progesterone Negative Feedback on Gonadotropin-Releasing Hormone Neurons in Sheep.

R. L. Goodman, L. M. Coolen, G. M. Anderson, S. L. Hardy, M. Valent, J. M. Connors, M. E. Fitzgerald, and M. N. Lehman (2004)
Endocrinology 145, 2959-2967
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Salvinorin A, an Active Component of the Hallucinogenic Sage Salvia divinorum Is a Highly Efficacious {kappa}-Opioid Receptor Agonist: Structural and Functional Considerations.

C. Chavkin, S. Sud, W. Jin, J. Stewart, J. K. Zjawiony, D. J. Siebert, B. A. Toth, S. J. Hufeisen, and B. L. Roth (2004)
J. Pharmacol. Exp. Ther. 308, 1197-1203
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Cloning and Characterization of Xen-dorphin Prohormone from Xenopus laevis: A NEW OPIOID-LIKE PROHORMONE DISTINCT FROM PROENKEPHALIN AND PRODYNORPHIN.

P. Pattee, A.-E. Ilie, S. Benyhe, G. Toth, A. Borsodi, and S. R. Nagalla (2003)
J. Biol. Chem. 278, 53098-53104
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Suppressed Prolactin Response to Dynorphin A1-13 in Methadone-Maintained Versus Control Subjects.

G. Bart, L. Borg, J. H. Schluger, M. Green, A. Ho, and M. J. Kreek (2003)
J. Pharmacol. Exp. Ther. 306, 581-587
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{kappa} Opioid Receptor Antagonism and Prodynorphin Gene Disruption Block Stress-Induced Behavioral Responses.

J. P. McLaughlin, M. Marton-Popovici, and C. Chavkin (2003)
J. Neurosci. 23, 5674-5683
 |  Abstract »  |  Full Text »  |  PDF »

Salvinorin A: A potent naturally occurring nonnitrogenous kappa opioid selective agonist.

B. L. Roth, K. Baner, R. Westkaemper, D. Siebert, K. C. Rice, S. Steinberg, P. Ernsberger, and R. B. Rothman (2002)
PNAS 99, 11934-11939
 |  Abstract »  |  Full Text »  |  PDF »

8-Carboxamidocyclazocine: A Long-Acting, Novel Benzomorphan.

J. M. Bidlack, D. J. Cohen, J. P. McLaughlin, R. Lou, Y. Ye, and M. P. Wentland (2002)
J. Pharmacol. Exp. Ther. 302, 374-380
 |  Abstract »  |  Full Text »  |  PDF »

Dynorphin A1-17-Induced Feeding: Pharmacological Characterization Using Selective Opioid Antagonists and Antisense Probes in Rats.

R. M. Silva, H. C. Grossman, M. M. Hadjimarkou, G. C. Rossi, G. W. Pasternak, and R. J. Bodnar (2002)
J. Pharmacol. Exp. Ther. 301, 513-518
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms of Induction of Persistent Nociception by Dynorphin.

T. M. Laughlin, A. A. Larson, and G. L. Wilcox (2001)
J. Pharmacol. Exp. Ther. 299, 6-11
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Altered Responsiveness to Cocaine and Increased Immobility in the Forced Swim Test Associated with Elevated cAMP Response Element-Binding Protein Expression in Nucleus Accumbens.

A. M. Pliakas, R. R. Carlson, R. L. Neve, C. Konradi, E. J. Nestler, and W. A. Carlezon Jr (2001)
J. Neurosci. 21, 7397-7403
 |  Abstract »  |  Full Text »  |  PDF »

Neuropathic Pain: The Paradox of Dynorphin.

J. Lai, M. H. Ossipov, T. W. Vanderah, T. P. Malan Jr., and F. Porreca (2001)
Mol. Interv. 1, 160-167
 |  Abstract »  |  Full Text »  |  PDF »

Dynorphin Exerts Both Postsynaptic and Presynaptic Effects in the Globus Pallidus of the Rat.

M. Ogura and H. Kita (2000)
J Neurophysiol 83, 3366-3376
 |  Abstract »  |  Full Text »  |  PDF »

High-Affinity Interaction of (des-Tyrosyl)Dynorphin A(2-17) with NMDA Receptors.

Q. Tang, R. Gandhoke, A. Burritt, V. J. Hruby, F. Porreca, and J. Lai (1999)
J. Pharmacol. Exp. Ther. 291, 760-765
 |  Abstract »  |  Full Text »

Dynorphin Selectively Augments the M-Current in Hippocampal CA1 Neurons by an Opiate Receptor Mechanism.

S. G. Madamba, P. Schweitzer, and G. R. Siggins (1999)
J Neurophysiol 82, 1768-1775
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Systemically Administered Dynorphin A(1-17) in Rhesus Monkeys.

E. R. Butelman, T. J. Harris, A. Perez, and M.-J. Kreek (1999)
J. Pharmacol. Exp. Ther. 290, 678-686
 |  Abstract »  |  Full Text »

Cellular Sites for Dynorphin Activation of kappa -Opioid Receptors in the Rat Nucleus Accumbens Shell.

A. L. Svingos, E. E. O. Colago, and V. M. Pickel (1999)
J. Neurosci. 19, 1804-1813
 |  Abstract »  |  Full Text »  |  PDF »

Dynorphin A1-13 Causes Elevation of Serum Levels of Prolactin Through an Opioid Receptor Mechanism in Humans: Gender Differences and Implications for Modulation of Dopaminergic Tone in the Treatment of Addictions.

M. J. Kreek, J. Schluger, L. Borg, M. Gunduz, and A. Ho (1999)
J. Pharmacol. Exp. Ther. 288, 260-269
 |  Abstract »  |  Full Text »

Regulation of Cocaine Reward by CREB.

W. A. Carlezon Jr., J. Thome, V. G. Olson, S. B. Lane-Ladd, E. S. Brodkin, N. Hiroi, R. S. Duman, R. L. Neve, and E. J. Nestler (1998)
Science 282, 2272-2275
 |  Abstract »  |  Full Text »

Effects of Kappa Opioid Agonists on Cocaine- and Food-Maintained Responding by Rhesus Monkeys.

N. K. Mello and S. S. Negus (1998)
J. Pharmacol. Exp. Ther. 286, 812-824
 |  Abstract »  |  Full Text »

Dynorphin A as a Potential Endogenous Ligand for Four Members of the Opioid Receptor Gene Family.

S. Zhang, Y. Tong, M. Tian, R. N. Dehaven, L. Cortesburgos, E. Mansson, F. Simonin, B. Kieffer, and L. Yu (1998)
J. Pharmacol. Exp. Ther. 286, 136-141
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Nuclear Opioid Receptors Activate Opioid Peptide Gene Transcription in Isolated Myocardial Nuclei.

C. Ventura, M. Maioli, G. Pintus, A. M. Posadino, and B. Tadolini (1998)
J. Biol. Chem. 273, 13383-13386
 |  Abstract »  |  Full Text »  |  PDF »

Administered and Endogenously Released Kappa Opioids Decrease Pilocarpine-Induced Seizures and Seizure-Induced Histopathology.

S. B. Bausch, T. M. Esteb, G. W. Terman, and C. Chavkin (1998)
J. Pharmacol. Exp. Ther. 284, 1147-1155
 |  Abstract »  |  Full Text »

Potentiation of NMDA Receptor-Mediated Responses by Dynorphin at Low Extracellular Glycine Concentrations.

L. Zhang, R. W. Peoples, M. Oz, J. Harvey-White, F. F. Weight, and U. Brauneis (1997)
J Neurophysiol 78, 582-590
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Kappa Opioids on Cocaine Self-Administration by Rhesus Monkeys.

S. S. Negus, N. K. Mello, P. S. Portoghese, and C.-E. Lin (1997)
J. Pharmacol. Exp. Ther. 282, 44-55
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M. K. Greenwald, M. L. Stitzer, and K. A. Haberny (1997)
J. Pharmacol. Exp. Ther. 281, 1154-1163
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Involvement of Dynorphin B in the Antinociceptive Effects of the Cannabinoid CP55,940 in the Spinal Cord.

G. Pugh Jr., D. J. Mason Jr., V. Combs, and S. P. Welch (1997)
J. Pharmacol. Exp. Ther. 281, 730-737
 |  Abstract »  |  Full Text »

Opioid Peptide Gene Expression in the Primary Hereditary Cardiomyopathy of the Syrian Hamster. I. REGULATION OF PRODYNORPHIN GENE EXPRESSION BY NUCLEAR PROTEIN KINASE C.

C. Ventura, G. Pintus, M. G. Fiori, F. Bennardini, G. Pinna, and L. Gaspa (1997)
J. Biol. Chem. 272, 6685-6692
 |  Abstract »  |  Full Text »  |  PDF »

Opioid Peptide Gene Expression in the Primary Hereditary Cardiomyopathy of the Syrian Hamster. II. ROLE OF INTRACELLULAR CALCIUM LOADING.

C. Ventura, G. Pintus, and B. Tadolini (1997)
J. Biol. Chem. 272, 6693-6698
 |  Abstract »  |  Full Text »  |  PDF »

Opioid Peptide Gene Expression in the Primary Hereditary Cardiomyopathy of the Syrian Hamster. III. AUTOCRINE STIMULATION OF PRODYNORPHIN GENE EXPRESSION BY DYNORPHIN B.

C. Ventura and G. Pintus (1997)
J. Biol. Chem. 272, 6699-6705
 |  Abstract »  |  Full Text »  |  PDF »

Dynorphin A1-13 Stimulates Ovine Fetal Pituitary-Adrenal Function through a Novel Nonopioid Mechanism.

C. C. Taylor, D. Wu, Y. Soong, J. S. Yee, and H. H. Szeto (1997)
J. Pharmacol. Exp. Ther. 280, 416-421
 |  Abstract »  |  Full Text »

Sensitivity of Opioid Receptor-like Receptor ORL1 for Chemical Modification on Nociceptin, a Naturally Occurring Nociceptive Peptide.

Y. Shimohigashi, R. Hatano, T. Fujita, R. Nakashima, T. Nose, T. Sujaku, A. Saigo, K. Shinjo, and A. Nagahisa (1996)
J. Biol. Chem. 271, 23642-23645
 |  Abstract »  |  Full Text »  |  PDF »

Phorbol Ester Regulation of Opioid Peptide Gene Expression in Myocardial Cells.

C. Ventura, G. Pintus, I. Vaona, F. Bennardini, G. Pinna, and B. Tadolini (1995)
J. Biol. Chem. 270, 30115-30120
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Dynorphins as Endogenous Ligands for an Opioid Receptor-like Orphan Receptor.

S. Zhang and L. Yu (1995)
J. Biol. Chem. 270, 22772-22776
 |  Abstract »  |  Full Text »  |  PDF »

Structure and Expression of a Rat kappa Opioid Receptor Gene.

A. G. Yakovlev, K. E. Krueger, and A. I. Faden (1995)
J. Biol. Chem. 270, 6421-6424
 |  Abstract »  |  Full Text »  |  PDF »

An all D-amino acid opioid peptide with central analgesic activity from a combinatorial library.

C. Dooley, N. Chung, B. Wilkes, P. Schiller, J. Bidlack, G. Pasternak, and R. Houghten (1994)
Science 266, 2019-2022
 |  Abstract »  |  PDF »

Comparison of the Neuroprotective Effects of the N-Methyl-D-Aspartate Antagonist MK-801 and the Opiate-Receptor Antagonist Nalmefene in Experimental Spinal Cord Ischemia.

S. W. Yum and A. I. Faden (1990)
Arch Neurol 47, 277-281
 |  Abstract »  |  PDF »

Pituitary Gland: Neuropeptides, Neurotransmitters and Growth Factors.

J. I. Koenig (1989)
Toxicol Pathol 17, 256-265
 |  Abstract »  |  PDF »

Peptide-dopamine interactions in the central nervous system: implications for neuropsychiatric disorders.

A.J. Stoessl (1989)
J Psychopharmacol 3, 99-120
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The opioid peptide dynorphin, circadian rhythms, and starvation.

R Przewlocki, W Lason, A. Konecka, C Gramsch, A Herz, and L. Reid (1983)
Science 219, 71-73
 |  Abstract »  |  PDF »

The Enkephalinergic Neuron: Implications of a Polyenkephalin Precursor.

J. Rossier, D. Liston, G. Patey, M. Chaminade, A.S. Foutz, A. Cupo, P. Giraud, M.P. Roisin, J.P. Henry, P. Verbanck, et al. (1983)
Cold Spring Harb Symp Quant Biol 48, 393-404
 |  Abstract »  |  PDF »

Nonopiate effects of dynorphin and des-Tyr-dynorphin.

J. Walker, H. Moises, D. Coy, G Baldrighi, and H Akil (1982)
Science 218, 1136-1138
 |  Abstract »  |  PDF »

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