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Science 22 January 1982:
Vol. 215. no. 4531, pp. 411 - 413
DOI: 10.1126/science.6173921
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Articles

Science, Vol 215, Issue 4531, 411-413
Copyright © 1982 by American Association for the Advancement of Science

articles

Molecular weight of human gamma interferon is similar to that of other human interferons

YK Yip, BS Barrowclough, C Urban, and J Vilcek

The molecular weight (as determined by molecular sieve chromatography) of human gamma interferon, formerly referred to as immune or type II interferon, is between 40,000 and 70,000. On sodium dodecyl sulfate-polyacrylamide gel electrophoresis, gamma interferon activity was recovered mainly from two regions of the gels corresponding to molecular weights of 20,000 and 25,000. The results suggest that in native form human gamma interferon may be aggregated.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Systemic lupus erythematosus: presence in human serum of an unusual acid-labile leukocyte interferon.
O. Preble, R. Black, R. Friedman, J. Klippel, and J Vilcek (1982)
Science 216, 429-431
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