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Science 22 January 1982:
Vol. 215. no. 4531, pp. 407 - 409
DOI: 10.1126/science.7058324
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Articles

Science, Vol 215, Issue 4531, 407-409
Copyright © 1982 by American Association for the Advancement of Science

articles

An inhibitor of the binding of thyroid hormones to serum proteins is present in extrathyroidal tissues

IJ Chopra, DH Solomon, GN Teco, and JB Eisenberg

Extrathyroidal tissues of man and the rat contain a potent inhibitor of the binding of thyroid hormones to serum proteins and to an anion-exchange resin. The inhibitor is heat-labile and nondialyzable. It acts by reducing the binding affinity of thyroid hormones to serum proteins, not by reducing the number of binding sites. The tissue inhibitor is similar in several characteristics to an inhibitor described previously in the serum of some critically ill patients, suggesting that the tissue inhibitor may leak into the circulation in severe illnesses.


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Alterations in Serum Thyroid Hormonal Indices with Colestipol-Niacin Therapy.
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Thyroid Function in Nonthyroidal Illnesses.
I. J. CHOPRA, J. M. HERSHMAN, W. M. PARDRIDGE, and J. T. NICOLOFF (1983)
Ann Intern Med 98, 946-957
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Euthyroid Hyperthyroxinemia.
G. C. BORST, C. EIL, and K. D. BURMAN (1983)
Ann Intern Med 98, 366-378
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Depressed Thyroid Indexes Associated With Occupational Exposure to Inorganic Lead.
J. M. Robins, M. R. Cullen, B. B. Connors, and R. D. Kayne (1983)
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