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Science 22 January 1982:
Vol. 215. no. 4531, pp. 399 - 400
DOI: 10.1126/science.7199205
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Articles

Science, Vol 215, Issue 4531, 399-400
Copyright © 1982 by American Association for the Advancement of Science

articles

Biosynthesis and processing of a human precursor complement protein, pro-C3, in a hepatoma-derived cell line

KM Morris, G Goldberger, HR Colten, DP Aden, and BB Knowles

A 180,000-dalton single-chain molecule (human pro-C3) is the precursor of the third component of human complement (C3), a disulfide-linked two-chain protein. The pro-C3 is converted by limited proteolysis to C3. The relationship between pro-C3 and C3 was established with the use of Hep G2, a cell line derived from a human hepatocellular carcinoma, which synthesizes at least 17 plasma proteins.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)