Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 15 January 1982:
Vol. 215. no. 4530, pp. 301 - 303
DOI: 10.1126/science.6797069
Prev | Table of Contents | Next

Articles

Science, Vol 215, Issue 4530, 301-303
Copyright © 1982 by American Association for the Advancement of Science

articles

Migration inhibition of endothelial cells by lymphokine-containing supernatants

MC Cohen, PT Picciano, WJ Douglas, T Yoshida, DL Kreutzer, and S Cohen

Many of the reactions of cellular immunity are mediated by soluble lymphocyte-derived factors (lymphokines). One important category of lymphokine action involves effects on cell motility. These effects have been described mainly with respect to inflammatory cells. In this report, we describe the ability of a lymphocyte product to inhibit the migration of endothelial cells in a system in vitro. The responsible factor is distinct from a previously described mediator that inhibits the migration of tumor cells. The ability of lymphocytes to influence the migration properties of endothelial cells is consistent with data of others showing a relation between the immune system and processes involving neovascularization.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Prostacyclin synthesis induced in vascular cells by interleukin-1.
V Rossi, F Breviario, P Ghezzi, E Dejana, and A Mantovani (1985)
Science 229, 174-176
   Abstract »    PDF »
Angiokines, Angiogenesis and Angiolymphoproliferative Syndromes (ALPS).
S. DeCarvalho (1983)
Angiology 34, 231-243
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)