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Science 15 January 1982:
Vol. 215. no. 4530, pp. 252 - 259
DOI: 10.1126/science.7053574
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Articles
Science, Vol 215, Issue 4530, 252-259
Copyright © 1982 by American Association for the Advancement of Science
Human cell hybrids: analysis of transformation and tumorigenicity
EJ Stanbridge,
CJ Der,
CJ Doersen,
RY Nishimi,
DM Peehl,
BE Weissman,
and
JE Wilkinson
Intraspecific human-human cell hybrids provide a stable model system with which to investigate the genetic control of transformed and tumorigenic phenotypes. Using this system it has been shown that these phenotypes are under separate genetic control. Furthermore, the tumorigenic phenotype can be complemented by fusion of different tumorigenic cells, resulting in nontumorigenic hybrids. This system also provides information on the control of differentiated function. Molecular cytogenetic techniques should reveal the nature of the chromosomal control of neoplastic transformation.
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