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Science 8 January 1982:
Vol. 215. no. 4529, pp. 182 - 184
DOI: 10.1126/science.7053569
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Articles

Science, Vol 215, Issue 4529, 182-184
Copyright © 1982 by American Association for the Advancement of Science

articles

Is the acetylcholine receptor a rabies virus receptor?

TL Lentz, TG Burrage, AL Smith, J Crick, and GH Tignor

Rabies virus was found on mouse diaphragms and on cultured chick myotubes in a distribution coinciding with that of the acetylcholine receptor. Treatment of the myotubes with alpha-bungarotoxin and d-tubocurarine before the addition of the virus reduced the number of myotubes that became infected with rabies virus. These findings together suggest that acetylcholine receptors may serve as receptors for rabies virus. The binding of virus to acetylcholine receptors, which are present in high density at the neuromuscular junction, would provide a mechanism whereby the virus could be locally concentrated at sites in proximity to peripheral nerves facilitating subsequent uptake and transfer to the central nervous system.


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