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Science 8 January 1982:
Vol. 215. no. 4529, pp. 181 - 182
DOI: 10.1126/science.6274023

Articles

Science, Vol 215, Issue 4529, 181-182
Copyright © 1982 by American Association for the Advancement of Science


articles

Specific chromosome defect associated with human small-cell lung cancer; deletion 3p(14-23)

J Whang-Peng, CS Kao-Shan, EC Lee, PA Bunn, DN Carney, AF Gazdar, and JD Minna

A specific, acquired chromosomal abnormality (deletion 3p) has been found in at least one chromosome 3 in 100 percent of the metaphases in 12 of 12 cell lines cultured from human small-cell lung cancer tissue and in 2-day tumor culture specimens from three patients. Analysis of the shortest region of overlap shows the deletion to be 3p(14-23). This specific change was not seen in five of five lung cancer cell lines other than small-cell lung cancer or in two lymphoblastoid lines cultured from cells of small-cell lung cancer patients whose tumors had the 3p deletion.


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