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ArticlesCopyright © 1982 by American Association for the Advancement of Science
Luteal phase defects induced by an agonist of luteinizing hormone-releasing factor: a model for fertility control
Subcutaneous injection of 50 micrograms of a luteinizing hormone-releasing factor agonist (LRF agonist) for three successive days at the time of menstruation in normal cycling women induces a shortened luteal phase with suboptimal concentrations of circulating estradiol and progesterone. This luteal phase defect follows a reduced concentration of follicle-stimulating hormone during the follicular phase and a resulting inadequate follicular maturation. Since a short luteal phase is associated with an endometrium not conductive to implantation, administration of the LRF agonist at the onset of menstrual cycle may prove to be a practical and novel approach to fertility control.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)
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