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Science 1 January 1982:
Vol. 215. no. 4528, pp. 79 - 81
DOI: 10.1126/science.7053561
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Articles

Science, Vol 215, Issue 4528, 79-81
Copyright © 1982 by American Association for the Advancement of Science

articles

Coupling of histone and DNA synthesis in the somatic cell cycle

AM Delegeane and AS Lee

The coupling of histone and DNA synthesis was examined in the temperature-sensitive hamster fibroblast cell line K12. By monitoring total cellular histone synthesis at various times after quiescent cells were stimulated to proliferate at permissive and nonpermissive temperatures, a direct correlation was found between the rates of DNA and histone synthesis. Furthermore, when DNA synthesis was blocked by the K12 mutation, histone synthesis was reduced to the basal rate.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Isolation of a mammalian sequence capable of conferring cell cycle regulation to a heterologous gene.
A Artishevsky, A Grafsky, and A. Lee (1985)
Science 230, 1061-1063
   Abstract »    PDF »
Clustering of human H1 and core histone genes.
N Carozzi, F Marashi, M Plumb, S Zimmerman, A Zimmerman, L. Coles, Wells JR, G Stein, and J Stein (1984)
Science 224, 1115-1117
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)