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Science 18 December 1981:
Vol. 214. no. 4527, pp. 1366 - 1368
DOI: 10.1126/science.6975999
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Articles

Science, Vol 214, Issue 4527, 1366-1368
Copyright © 1981 by American Association for the Advancement of Science

articles

Intracranial self-stimulation in 3-day-old rat pups

TH Moran, MF Lew, and EM Blass

Three-day-old rat pups with electrodes directed at the medial forebrain bundle at the level of the lateral hypothalamic area were trained to push a paddle to receive electrical brain stimulation. Pups receiving stimulation that was contingent on lifting the paddle responded more frequently than did control pups and also learned a two-choice spatial discrimination task that was rewarded with brain stimulation. The experiments indicate that a neural substrate in the area of the medial forebrain bundle is involved in the central mediation of reinforcement in the rat pup.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Melanin concentrating hormone depresses synaptic activity of glutamate and GABA neurons from rat lateral hypothalamus.
X.-B. Gao and A. N van den Pol (2001)
J. Physiol. 533, 237-252
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