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Science 18 December 1981:
Vol. 214. no. 4527, pp. 1357 - 1359
DOI: 10.1126/science.7313695
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Articles

Science, Vol 214, Issue 4527, 1357-1359
Copyright © 1981 by American Association for the Advancement of Science

articles

Epithelial cell volume regulation: bicarbonate dependence

RS Fisher, BE Persson, and KR Spring

When Necturus gallbladder epithelial cells are osmotically shrunken, they rapidly return to their original volume despite the continued presence of a hypertonic bathing solution. This volume-regulatory process requires bicarbonate ions in the bathing solutions and is associated with the uptake of chloride ions. Volume-regulatory increase by epithelial cells in probable due to the parallel operation of sodium-hydrogen and chloride-bicarbonate exchangers in the apical cell membrane.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)