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Science 18 December 1981:
Vol. 214. no. 4527, pp. 1355 - 1357
DOI: 10.1126/science.6274017
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Articles

Science, Vol 214, Issue 4527, 1355-1357
Copyright © 1981 by American Association for the Advancement of Science

articles

Regulation of muscle differentiation: stimulation of myoblast fusion in vitro by catecholamines

DH Curtis and RJ Zalin

Epinephrine and isoproterenol provoke primary chick myoblasts to initiate precocious cell fusion. Both the rise in intracellular adenosine 3' ,5-monophosphate (cyclic AMP) and cell fusion generated by these effectors are prevented by propranolol, which is a specific blocker of the beta-adrenergic receptor. Propranolol has no effect either on the precocious cell fusion provoked by prostaglandin E or on cell fusion in control cultures. The results support the idea that a rise in cyclic AMP is the critical intracellular change responsible for initiating events that culminate in myoblast differentiation 4 to 5 hours later. They also indicate that the culminate in myoblast differentiation 4 to 5 hours later. They also indicate that the hormone responsible for the positive regulation of myoblast differentiation in vitro is not acting through the beta-adrenergic receptor.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Nuclear import of the myogenic factor MyoD requires cAMP-dependent protein kinase activity but not the direct phosphorylation of MyoD.
M Vandromme, G Carnac, C Gauthier-Rouviere, D Fesquet, N Lamb, and A Fernandez (1994)
J. Cell Sci. 107, 613-620
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