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Science 18 December 1981:
Vol. 214. no. 4527, pp. 1350 - 1353
DOI: 10.1126/science.7313693
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Articles

Science, Vol 214, Issue 4527, 1350-1353
Copyright © 1981 by American Association for the Advancement of Science

articles

Phase locking, period-doubling bifurcations, and irregular dynamics in periodically stimulated cardiac cells

MR Guevara, L Glass, and A Shrier

The spontaneous rhythmic activity of aggregates of embryonic chick heart cells was perturbed by the injection of single current pulses and periodic trains of current pulses. The regular and irregular dynamics produced by periodic stimulation were predicted theoretically from a mathematical analysis of the response to single pulses. Period-doubling bifurcations, in which the period of a regular oscillation doubles, were predicted theoretically and observed experimentally.


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