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Science 18 December 1981:
Vol. 214. no. 4527, pp. 1346 - 1348
DOI: 10.1126/science.6274016
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Articles

Science, Vol 214, Issue 4527, 1346-1348
Copyright © 1981 by American Association for the Advancement of Science

articles

Gonadotropin-releasing hormone: regulation of adenosine 3',5'-monophosphate in ovarian granulosa cells

M Knecht and KJ Catt

The antigonadal effects of gonadotropin-releasing hormone in ovarian granulosa cells are due to attenuation of the adenosine 3',5'-monophosphate (cyclic AMP) response to follicle-stimulating hormone. Agonists of gonadotropin-releasing hormone progressively inhibit adenylate cyclase and stimulate phosphodiesterase activities in cultured granulosa cells, indicating that blockade of gonadotropin action is attributable to the combined effects of decreased production and increased degradation of cyclic AMP.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Yeast mating pheromone activates mammalian gonadotrophs: evolutionary conservation of a reproductive hormone?.
E Loumaye, J Thorner, and K. Catt (1982)
Science 218, 1323-1325
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