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Science 11 December 1981:
Vol. 214. no. 4526, pp. 1237 - 1239
DOI: 10.1126/science.6272396
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Articles

Science, Vol 214, Issue 4526, 1237-1239
Copyright © 1981 by American Association for the Advancement of Science

articles

Adenosine 3',5'-monophosphate modulates thyrotropin receptor clustering and thyrotropin activity in culture

A Avivi, D Tramontano, FS Ambesi-Impiombato, and J Schlessinger

A biologically active rhodamine conjugate of thyrotropin binds at 4 degrees C to diffusely distributed membrane thyrotropin receptors which patch and become endocytosed into thyroid cells in a temperature-sensitive process. When the cells are first incubated with 8-bromo-cyclic adenosine monophosphate at 37 degrees C, the conjugate also binds to clustered receptors at 4 degrees C. Furthermore, 8-bromo-cyclic adenosine monophosphate reduces the amount of adenosine 3',5'-monophosphate (cyclic AMP) induced by thyrotropin. Hence, increased intracellular cyclic AMP induces receptor patching and reduces the concentration of cyclic AMP normally induced by thyrotropin. This suggests that cyclic AMP acts both as the second messenger of thyrotropin and also as the regulator of the level of thyrotropin receptors.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Upon Thyrotropin Binding the Thyrotropin Receptor Is Internalized and Localized to Endosome.
S. P. Singh, D. McDonald, T. J. Hope, and B. S. Prabhakar (2004)
Endocrinology 145, 1003-1010
   Abstract »    Full Text »    PDF »
Internalization and Recycling Pathways of the Thyrotropin Receptor.
C. Baratti-Elbaz, N. Ghinea, O. Lahuna, H. Loosfelt, C. Pichon, and E. Milgrom (1999)
Mol. Endocrinol. 13, 1751-1765
   Abstract »    Full Text »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)