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Science 4 December 1981:
Vol. 214. no. 4525, pp. 1145 - 1147
DOI: 10.1126/science.7302587
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Articles

Science, Vol 214, Issue 4525, 1145-1147
Copyright © 1981 by American Association for the Advancement of Science

articles

Reduction in oocyte number following prenatal exposure to a diet high in galactose

YT Chen, DR Mattison, L Feigenbaum, H Fukui, and JD Schulman

When pregnant rats were fed a 50 percent galactose diet there was a striking reduction in oocyte number in the offspring. The most prominent effects were noted after exposure to galactose during the premeiotic stages of oogenesis. Prenatal exposure to galactose or its metabolites may contribute to the premature ovarian failure characteristic of human galactosemia.


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Pathophysiology of impaired ovarian function in galactosaemia.
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Hum. Reprod. Update 12, 573-584
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Chronic Exposure to Dibromoacetic Acid, a Water Disinfection Byproduct, Diminishes Primordial Follicle Populations in the Rabbit.
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Toxicol. Sci. 80, 83-91
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Galactose toxicity in the rat as a model for premature ovarian failure: an experimental approach readdressed.
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GALT deficiency causes UDP-hexose deficit in human galactosemic cells.
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Prenatal exposure to high galactose adversely affects initial gonadal pool of germ cells in rats*.
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Lactose Intolerance.
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Absence of a relationship between endometriosis and the N314D polymorphism of galactose-1-phosphate uridyl transferase in a UK population.
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Premature Ovarian Failure and Ovarian Autoimmunity.
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