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Science 4 December 1981:
Vol. 214. no. 4525, pp. 1137 - 1139
DOI: 10.1126/science.6795718
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Articles

Science, Vol 214, Issue 4525, 1137-1139
Copyright © 1981 by American Association for the Advancement of Science

articles

Inhibition of purine nucleoside phosphorylase by 8-aminoguanosine: selective toxicity for T lymphoblasts

IS Kazmers, BS Mitchell, PE Dadonna, LL Wotring, LB Townsend, and WN Kelley

The guanosine analog 8-aminoguanosine is an effective inhibitor of the purine degradative enzyme purine nucleoside phosphorylase, both in vitro and in intact lymphoid cells. In a human lymphoblast tissue culture system, 8-aminoguanosine, in combination with low concentrations of 2'-deoxyguanosine, causes toxicity toward T cells but not B cells. The selective T cell toxicity correlates with increased accumulation of deoxyguanosine triphosphate in the treated T lymphoblasts.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A proof-of-principle pharmacokinetic, pharmacodynamic, and clinical study with purine nucleoside phosphorylase inhibitor immucillin-H (BCX-1777, forodesine).
V. Gandhi, J. M. Kilpatrick, W. Plunkett, M. Ayres, L. Harman, M. Du, S. Bantia, J. Davisson, W. G. Wierda, S. Faderl, et al. (2005)
Blood 106, 4253-4260
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Science. ISSN 0036-8075 (print), 1095-9203 (online)