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Science 27 November 1981:
Vol. 214. no. 4524, pp. 1036 - 1038
DOI: 10.1126/science.6272394
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Articles

Science, Vol 214, Issue 4524, 1036-1038
Copyright © 1981 by American Association for the Advancement of Science

articles

Quantitative autoradiography of [3H]muscimol binding in rat brain

JB Penney Jr, HS Pan, AB Young, KA Frey, and GW Dauth

A simple quantitative autoradiographic technique for the study of neurotransmitter receptors that includes the use of a tritium-sensitive film permits saturation, kinetic, and competition studies of brain samples as small as 0.01 cubic millimeter. This technique was used to study [3H]muscimol binding in rat brain. Unilateral gamma-aminobutyric acid receptor supersensitivity was observed in the substantia nigra pars reticulata after production of localized lesions of the ipsilateral corpus striatum.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride Neurotoxicity Is Attenuated in Mice Overexpressing Bcl-2.
L. Yang, R. T. Matthews, J. B. Schulz, T. Klockgether, A. W. Liao, J.-C. Martinou, J. B. Penney Jr., B. T. Hyman, and M. F. Beal (1998)
J. Neurosci. 18, 8145-8152
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