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Science 27 November 1981:
Vol. 214. no. 4524, pp. 1029 - 1031
DOI: 10.1126/science.6171036
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Articles

Science, Vol 214, Issue 4524, 1029-1031
Copyright © 1981 by American Association for the Advancement of Science

articles

A substance P antagonist, [D-Pro2, D-Trp7,9]SP, inhibits inflammatory responses in the rabbit eye

G Holmdahl, R Hakanson, S Leander, S Rosell, K Folkers, and F Sundler

Neurogenic factors released by antidromic nerve stimulation are thought to be in part responsible for the vasodilation and breakdown of the blood-aqueous barrier that follows trauma to the eye. Substance P is one candidate for the mediation of the inflammatory response since it is thought to be a neurotransmitter in sensory afferents and since exogenous substance P is capable of eliciting a response characteristic of inflammation. In rabbits, intravitreal or topical application onto the eye of a specific substance P antagonist, [d-Pro2, D-Trp7,9]SP, inhibited not only the irritant effects of exogenous substance P but also the inflammatory response to a standardized trauma (infrared irradiation of the iris). These observations suggest that substance P, or a related peptide, is a neurogenic mediator of the inflammatory response in the eye.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Substance P--like Immunoreactive Nerves in the Human Eye.
R. A. Stone and Y. Kuwayama (1985)
Arch Ophthalmol 103, 1207-1211
   Abstract »    PDF »
Pain and Analgesia: The Outlook for More Rational Treatment.
J. LEVINE (1984)
Ann Intern Med 100, 269-276
   Abstract »    PDF »


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