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Science 20 November 1981:
Vol. 214. no. 4523, pp. 923 - 924
DOI: 10.1126/science.6272393
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Articles

Science, Vol 214, Issue 4523, 923-924
Copyright © 1981 by American Association for the Advancement of Science

articles

Both mu and delta opiate receptors exist on the same neuron

TM Egan and RA North

Low concentrations of the relatively selective opiate receptor agonists dihydromorphine and normorphine (mu receptor agonists) and D-Ala 2-D-Leu 5-enkephalin (a delta receptor agonist) were applied to single enteric neurons while the frequency of action potential firing was recorded. Most neurons that were inhibited by the mu agonists were also inhibited by the delta agonist, but the two receptors could be distinguished by the higher concentration of naloxone required to antagonize the delta agonist. The results indicate that enteric neurons bear both mu and delta receptors and that cell firing is inhibited if either receptor type is activated.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Disruption of Cdk5-Associated Phosphorylation of Residue Threonine-161 of the {delta}-Opioid Receptor: Impaired Receptor Function and Attenuated Morphine Antinociceptive Tolerance.
W.-Y. Xie, Y. He, Y.-R. Yang, Y.-F. Li, K. Kang, B.-M. Xing, and Y. Wang (2009)
J. Neurosci. 29, 3551-3564
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A Role for the Distal Carboxyl Tails in Generating the Novel Pharmacology and G Protein Activation Profile of {micro} and {delta} Opioid Receptor Hetero-oligomers.
T. Fan, G. Varghese, T. Nguyen, R. Tse, B. F. O'Dowd, and S. R. George (2005)
J. Biol. Chem. 280, 38478-38488
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Characterization of Opioid Receptors Modulating Neurogenic Contractions of Circular Muscle from Porcine Ileum and Evidence That {delta}- and {kappa}-Opioid Receptors Are Coexpressed in Myenteric Neurons.
S. Poonyachoti, P. S. Portoghese, and D. R. Brown (2001)
J. Pharmacol. Exp. Ther. 297, 69-77
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Global form and singularity: modeling the blind spot's role in lateral geniculate morphogenesis.
D Lee and J. Malpeli (1994)
Science 263, 1292-1294
   Abstract »    PDF »
Heterodimerization of {micro} and delta Opioid Receptors: A Role in Opiate Synergy.
I. Gomes, B. A. Jordan, A. Gupta, N. Trapaidze, V. Nagy, and L. A. Devi (2000)
J. Neurosci. 20, RC110
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