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Science 20 November 1981:
Vol. 214. no. 4523, pp. 919 - 921
DOI: 10.1126/science.6117945
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Articles

Science, Vol 214, Issue 4523, 919-921
Copyright © 1981 by American Association for the Advancement of Science

articles

Tetrahydrobiopterin in striatum: localization in dopamine nerve terminals and role in catecholamine synthesis

RA Levine, LP Miller, and W Lovenberg

The hydroxylase cofactor, tetrahydrobiopterin, and its biosynthetic system are localized in dopaminergic nerve terminals in the striatum. This conclusion is based on the nearly equivalent loss of tyrosine hydroxylase and tetrahydrobiopterin and its initial biosynthetic enzyme, guanosine triphosphate cyclohydrolase, after injection of 6-hydroxydopamine into the substantia nigra. The role of the hydroxylase cofactor in the regulation of dopamine synthesis is reassessed.


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