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Science 13 November 1981:
Vol. 214. no. 4522, pp. 821 - 823
DOI: 10.1126/science.7292016
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Articles

Science, Vol 214, Issue 4522, 821-823
Copyright © 1981 by American Association for the Advancement of Science

articles

Melatonin: identification of sites of antigonadal action in mouse brain

JD Glass and GR Lynch

Long-term implants releasing a small quantity of melatonin (45 nanograms per day) were used to determine the brain sites of the hormone's antigonadal action in a photoperiodic species, the white-footed mouse (Peromyscus leucopus). Implants in the medial preoptic and supra- and retrochiasmatic areas elicited completed gonadal regression after 7 weeks. Implants in other brain regions had little effect on the animals' reproductive state.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Response to selection for photoperiod responsiveness on the density and location of mature GnRH-releasing neurons.
M. Avigdor, S. D. Sullivan, and P. D. Heideman (2005)
Am J Physiol Regulatory Integrative Comp Physiol 288, R1226-R1236
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Cellular Mechanisms of Melatonin Action.
J. VANECEK (1998)
Physiol Rev 78, 687-721
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Melatonin: a coordinating signal for mammalian reproduction?.
L Tamarkin, C. Baird, and O. Almeida (1985)
Science 227, 714-720
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