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Science 13 November 1981:
Vol. 214. no. 4522, pp. 805 - 807
DOI: 10.1126/science.7292012
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Articles

Science, Vol 214, Issue 4522, 805-807
Copyright © 1981 by American Association for the Advancement of Science

articles

Detection of circulating metallothionein in rats injected with zinc or cadmium

JS Garvey and CC Chang

Circulating metallothionein was measured by radioimmunoassay over a 13-day period in male Sprague-Dawley rats that received a sequence of three intraperitoneal injections (at 3-day intervals) of either 5 milligrams of zinc or 0.8 milligrams of cadmium per kilogram of body weight. These amounts of zinc and cadmium produced metallothionein concentrations in the range of 2 to 5 nanograms per milliliter of serum (zinc) and 2 to 15 nanograms per milliliter of serum (cadmium). In control rats given saline injections over the same period the metallothionein concentration ranged from 1 to 3 nanograms per milliliter of serum.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)