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Science 6 November 1981:
Vol. 214. no. 4521, pp. 678 - 681
DOI: 10.1126/science.6794147
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Articles

Science, Vol 214, Issue 4521, 678-681
Copyright © 1981 by American Association for the Advancement of Science

articles

Thyrotropin-releasing hormone effects in the central nervous system: dependence on arousal state

TL Stanton, AL Bechman, and A Winokur

Thyrotropin-releasing hormone was microinjected into the dorsal hippocampus of ground squirrels (Citellus lateralis) when they were at different levels of arousal, as assessed by electrophysiological and behavioral criteria. When administered to the awake animal, thyrotropin-releasing hormone produced dose-dependent decreases in body temperature accompanied by behavioral quieting and reductions in metabolic rate and electromyographic activity. The magnitude of these effects was greater when the peptide was microinjected during a period of behavioral activation. In contrast, administration of the peptide during slow wave sleep produced increased thermogenesis, an increase in electromyographic activity, and an increase in the amount of electroencephalographic desynchronization.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
CSF Thyrotropin-Releasing Hormone Gender Difference: Implications for Neurobiology and Treatment of Depression.
M. A. Frye, K. A. Gary, L. B. Marangell, M. S. George, A. M. Callahan, J. T. Little, T. Huggins, G. Corá-Locatelli, E. A. Osuch, A. Winokur, et al. (1999)
J Neuropsychiatry Clin Neurosci 11, 349-353
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Effects of Intrathecal Thyrotropin-Releasing Hormone (Protirelin) in Refractory Depressed Patients.
L. B. Marangell, M. S. George, A. M. Callahan, T. A. Ketter, P. J. Pazzaglia, T. A. L'Herrou, G. S. Leverich, and R. M. Post (1997)
Arch Gen Psychiatry 54, 214-222
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Carbamazepine Increases Cerebrospinal Fluid Thyrotropin-Releasing Hormone Levels in Affectively Ill Patients.
L. B. Marangell, M. S. George, G. Bissette, P. Pazzaglia, T. Huggins, and R. M. Post (1994)
Arch Gen Psychiatry 51, 625-628
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