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Science 6 November 1981:
Vol. 214. no. 4521, pp. 667 - 669
DOI: 10.1126/science.7027441
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Articles

Science, Vol 214, Issue 4521, 667-669
Copyright © 1981 by American Association for the Advancement of Science

articles

Hemin lyses malaria parasites

AU Orjih, HS Banyal, R Chevli, and CD Fitch

Malaria parasites isolated from mouse erythrocytes are lysed by ferriprotoporphyrin IX chloride (hemin) or by a chloroquine-hemin complex in amounts that could be produced by release of less than 0.1 percent of the heme in erythrocytic hemoglobin. This effect of hemin may explain the protection against malaria provided by thalassemia and other conditions causing intracellular denaturation of hemoglobin. The toxicity of the chloroquine-hemin complex may explain the selective antimalarial action of chloroquine.


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