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Science 30 October 1981:
Vol. 214. no. 4520, pp. 569 - 570
DOI: 10.1126/science.7291996
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Articles

Science, Vol 214, Issue 4520, 569-570
Copyright © 1981 by American Association for the Advancement of Science

articles

DNA synthesis in cultured adult cardiocytes

M Cantin, M Ballak, J Beuzeron-Mangina, MB Anand-Srivastava, and C Tautu

Trypsin-dissociated atrial cardiocytes from adult rats were exposed to [3H]thymidine for sequential 24-hour periods from day 2 to day 12 of culture. On day 3 and each day thereafter, cells were prepared for ultrastructural radioautography and examined with an electron microscope. Maximal incorporation occurred on day 5, when 63 percent of the cardiocytes were labeled. Mitotic activity was never present in more than 0.5 percent of the cardiocytes examined. Incorporation of [3H]thymidine and mitosis occurred only in immature cardiocytes characterized by subsarcolemmal primary filaments and Z bands with or without specific granules; more mature cardiocytes were never labeled.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Biosynthesis and secretion of proatrial natriuretic factor by cultured rat cardiocytes.
K. Bloch, J. Scott, J. Zisfein, J. Fallon, M. Margolies, C. Seidman, G. Matsueda, C. Homcy, R. Graham, and J. Seidman (1985)
Science 230, 1168-1171
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