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Science 30 October 1981:
Vol. 214. no. 4520, pp. 558 - 559
DOI: 10.1126/science.7291992
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Articles

Science, Vol 214, Issue 4520, 558-559
Copyright © 1981 by American Association for the Advancement of Science

articles

Effect of indomethacin on intestinal tumors induced in rats by the acetate derivative of dimethylnitrosamine

M Pollard and PH Luckert

Over the course of 20 weeks, Sprague-Dawley rats developed intestinal tumors in response to an intraperitoneal injection of the acetate derivative of dimethylnitrosamine. The same agent did not induce tumors in Lobund-Wistar rats. The number of tumors was significantly smaller in rats given drinking water containing indomethacin (beginning 14 days after the injections) than in control rats given drug-free water.


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