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Science 30 October 1981:
Vol. 214. no. 4520, pp. 504 - 509
DOI: 10.1126/science.6170111
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Articles

Science, Vol 214, Issue 4520, 504-509
Copyright © 1981 by American Association for the Advancement of Science

articles

Journey to the center of the cell: role of the receptosome

IH Pastan and MC Willingham

Fibroblasts contain a specific internalization pathway that carries hormones as well as some proteins and viruses from the cell surface to the cell interior. Initially, the ligands bind to mobile receptors that are randomly distributed on the cell surface. Next the ligand-receptor complexes are trapped and concentrated in specialized regions of the membrane termed bristle-coated pits. From the pit a smooth-walled vesicle containing the ligand forms and carries the ligand to the cell interior. Because of its role in receptor-mediated endocytosis, this vesicle has been termed a "receptosome."


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A receptor-mediated pathway for cholesterol homeostasis.
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Externalization of beta-adrenergic receptors promoted by myocardial ischemia.
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Ammonium chloride prevents lytic growth of reovirus and helps to establish persistent infection in mouse L cells.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)