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Science 23 October 1981:
Vol. 214. no. 4519, pp. 470 - 471
DOI: 10.1126/science.7291989
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Articles

Science, Vol 214, Issue 4519, 470-471
Copyright © 1981 by American Association for the Advancement of Science

articles

Brain pyruvate dehydrogenase: phosphorylation and enzyme activity altered by a training experience

DG Morgan and A Routtenberg

The active portion of the alpha subunit of pyruvate dehydrogenase in rat frontal cortex was elevated after a training experience. No change in total pyruvate dehydrogenase activity was observed. The phosphorylation in vitro of pyruvate dehydrogenase (band F-2) was also elevated after training. Since activation of pyruvate dehydrogenase requires its dephosphorylation, the following sequence is proposed. Training alters frontal cortex and reduces the phosphate content of pyruvate dehydrogenase in vivo; this leads to enzyme activation; and an increase in back-titration of sites available for phosphorylation in vitro.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Entorhinal cortex lesions induce a decreased calcium transport in hippocampal mitochondria.
M Baudry, J Fuchs, M Kessler, D Arst, and G Lynch (1982)
Science 216, 411-413
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