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Science 23 October 1981:
Vol. 214. no. 4519, pp. 445 - 450
DOI: 10.1126/science.6170110
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Articles

Science, Vol 214, Issue 4519, 445-450
Copyright © 1981 by American Association for the Advancement of Science

articles

Complete nucleotide sequence and organization of the Moloney murine sarcoma virus genome

EP Reddy, MJ Smith, and SA Aaronson

The complete nucleotide sequence of a mammalian transforming retrovirus. Moloney murine sarcoma virus, has been determined. MSV, recombinant virus derived of helper viral and cellular sequences, possesses termini resembling prokaryotic transposable elements. The viral genome has the coding capacity for the Moloney murine leukemia virus gag gene product and contains large deletions in pol and env genes. A large open reading frame encompassing its cell-derived sequences codes for its putative transforming protein. The nature of some of the important domains in the viral genome has been established, and their structure is discussed in relation to their function.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Moloney Murine Sarcoma Virus Genomic RNAs Dimerize via a Two-Step Process: a Concentration-Dependent Kissing-Loop Interaction Is Driven by Initial Contact between Consecutive Guanines.
H. Ly, D. P. Nierlich, J. C. Olsen, and A. H. Kaplan (1999)
J. Virol. 73, 7255-7261
   Abstract »    Full Text »
Gene product of v-fgr onc: hybrid protein containing a portion of actin and a tyrosine-specific protein kinase.
G Naharro, K. Robbins, and E. Reddy (1984)
Science 223, 63-66
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)