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Science 23 October 1981:
Vol. 214. no. 4519, pp. 395 - 400
DOI: 10.1126/science.214.4519.395
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Articles

Acyclic Stereocontrol Through the Aldol Condensation

Clayton H. Heathcock 1

1 Professor of chemistry at the University of California, Berkeley 94720

For the scientist who wishes to synthesize complex organic compounds, the most difficult problem is often establishing the correct configuration at the various chiral centers as the synthesis is being carried out. In the past decade, there has been an increasing effort to find direct solutions to this problem, which is particularly acute in the synthesis of acyclic and other conformationally flexible molecules. One of the oldest organic reactions, the aldol condensation, is emerging as a powerful tool for use in achieving such stereocontrol.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Efficient Aldolase Catalytic Antibodies That Use the Enamine Mechanism of Natural Enzymes.
Jür. Wagner, R. A. Lerner, and C. F. Barbas III (1995)
Science 270, 1797-1800
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[2 + 2] photocycloadditions in the synthesis of chiral molecules.
S. Schreiber (1985)
Science 227, 857-863
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Current Status of Asymmetric Synthesis.
H. S. Mosher and J. D. Morrison (1983)
Science 221, 1013-1019
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