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Science 16 October 1981:
Vol. 214. no. 4518, pp. 335 - 336
DOI: 10.1126/science.6169153
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Articles

Science, Vol 214, Issue 4518, 335-336
Copyright © 1981 by American Association for the Advancement of Science

articles

Substance P in principal sympathetic neurons: regulation by impulse activity

JA Kessler, JE Adler, MC Bohn, and IB Black

Regulation of the putative peptide neurotransmitter substance P was examined in the superior cervical sympathetic ganglion of the neonatal rat. Surgical decentralization (denervation) of the superior cervical ganglion increased ganglion substance P content. In cultured ganglia, the amount of substance P increased more than 50-fold after 48 hours, and this rise was dependent on protein and RNA synthesis. Veratridine prevented the increase in substance P in vitro, and tetrodotoxin blocked the veratridine effect; this suggests that sodium influx and membrane depolarization prevent substance P elevation. Immunohistochemical analysis of cultured ganglia indicated that substance P was present in the perikarya of principal sympathetic neurons and in ganglionic nerve processes. Transsynaptic impulses, through the mediation of postsynaptic sodium influx, may decrease substance P in sympathetic neurons.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Substance P and neurokinin-1 receptor expression by intrinsic airway neurons in the rat.
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Development of Bone Morphogenetic Protein Receptors in the Nervous System and Possible Roles in Regulating trkC Expression.
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Biochemistry of information storage in the nervous system.
I. Black, J. Adler, C. Dreyfus, W. Friedman, E. LaGamma, and A. Roach (1987)
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Plasticity of substance P in mature and aged sympathetic neurons in culture.
J. Adler and I. Black (1984)
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Neurotransmitter plasticity at the molecular level.
I. Black, J. Adler, C. Dreyfus, G. Jonakait, D. Katz, E. LaGamma, and K. Markey (1984)
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Impulse activity differentially regulates [Leu]enkephalin and catecholamine characters in the adrenal medulla.
E. LaGamma, J. Adler, and I. Black (1984)
Science 224, 1102-1104
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Substance P and somatostatin regulate sympathetic noradrenergic function.
J. Kessler, J. Adler, and I. Black (1983)
Science 221, 1059-1061
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Stages of Neurotransmitter Development in Autonomic Neurons.
I. B. Black (1982)
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