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Science 9 October 1981:
Vol. 214. no. 4517, pp. 200 - 202
DOI: 10.1126/science.7280691
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Articles

Science, Vol 214, Issue 4517, 200-202
Copyright © 1981 by American Association for the Advancement of Science

articles

Sulfhydryl compounds may mediate gastric cytoprotection

S Szabo, JS Trier, and PW Frankel

Ethanol induces hemorrhagic gastric erosions and causes a dose-dependent decrease in the concentration of nonprotein sulfhydryl compounds in rat gastric mucosa. Sulfhydryl-containing drugs protect rats from ethanol-induced gastric erosions, whereas sulfhydryl blocking agents counteract the mucosal cytoprotective effect of prostaglandin F2 beta. These observations suggest that endogenous nonprotein sulfhydryls may mediate prostaglandin-induced gastric cytoprotection and that sulfhydryl drugs may have potential for preventing or treating hemorrhagic gastric erosions.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Investigation of gastroprotective compounds at subcellular level in isolated gastric mucosal cells.
L. Nagy, R. E. Morales, M. Beinborn, P. Vattay, and S. Szabo (2000)
Am J Physiol Gastrointest Liver Physiol 279, G1201-G1208
   Abstract »    Full Text »    PDF »
Role of Antioxidant Defenses Against Ethanol-Induced Damage in Cultured Rat Gastric Epithelial Cells.
H. Hiraishi, T. Shimada, K. J. Ivey, and A. Terano (1999)
J. Pharmacol. Exp. Ther. 289, 103-109
   Abstract »    Full Text »


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