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Science 9 October 1981:
Vol. 214. no. 4517, pp. 197 - 200
DOI: 10.1126/science.7025212
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Articles

Science, Vol 214, Issue 4517, 197-200
Copyright © 1981 by American Association for the Advancement of Science

articles

Vitamin D--dependent calcium binding protein: immunocytochemical localization in chick kidney

J Roth, B Thorens, W Hunziker, AW Norman, and L Orci

A vitamin D--dependent calcium binding protein in the chick kidney that was detected by immunocytochemical techniques was localized exclusively in the distal convoluted tubule, the initial collecting tubule, and the early part of the collecting tubule. The intercalated (mitochondria-rich) cells in these tubular segments were negative for the calcium binding protein. Subcellularly, the protein was found in the cytosol and the nucleus of the tubular cells. The results suggest a role for vitamin D--dependent calcium binding protein in intracellular calcium metabolism rather than a direct involvement in membrane-mediated calcium reabsorption in the avian kidney.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Identification of Megalin as the Sole Rat Kidney Sialoglycoprotein Containing Poly {alpha}2,8 Deaminoneuraminic Acid.
M. ZIAK, D. KERJASCHKI, M. G. FARQUHAR, and J. ROTH (1999)
J. Am. Soc. Nephrol. 10, 203-209
   Abstract »    Full Text »
Analysis of Vitamin D-Dependent Calcium-Binding Protein Messenger Ribonucleic Acid Expression in Mice Lacking the Vitamin D Receptor.
Y. C. Li, A. E. Pirro, and M. B. Demay (1998)
Endocrinology 139, 847-851
   Abstract »    Full Text »    PDF »


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