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Science 2 October 1981:
Vol. 214. no. 4516, pp. 85 - 86
DOI: 10.1126/science.6897930
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Articles

Science, Vol 214, Issue 4516, 85-86
Copyright © 1981 by American Association for the Advancement of Science

articles

Heart imaging with cationic complexes of technetium

E Deutsch, W Bushong, KA Glavan, RC Elder, VJ Sodd, KL Scholz, DL Fortman, and SJ Lukes

The cationic technetium-99 complex trans-[99TC(dmpe)2Cl2]+, where dmpe is bis(1,2-dimethylphosphino)ethane or (CH3)2P-CH2-P(CH3)2, has been prepared and characterized by single-crystal, x-ray structural analysis. The technetium-99m analog, trans-(99mTc(dmpe) 2Cl2]+, has also been prepared and shown to yield excellent gamma-ray images of the heart. The purposeful design, characterization, and synthesis of this technetium-99m radiopharmaceutical represents a striking application of fundamental inorganic chemistry to a problem in applied nuclear medicine.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)