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Science 2 October 1981:
Vol. 214. no. 4516, pp. 77 - 79
DOI: 10.1126/science.6269181
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Articles

Science, Vol 214, Issue 4516, 77-79
Copyright © 1981 by American Association for the Advancement of Science

articles

Growth arrest and morphological change of human breast cancer cells by dibutyryl cyclic AMP and L-arginine

YS Cho-Chung, T Clair, JS Bodwin, and B Berghoffer

The growth in vitro of human breast cancer cells, line MCF-7, was inhibited by a daily supplement of L-arginine (1 milligram per milliliter). Arginine acted synergistically with dibutyryl adenosine 3',5'-monophosphate (cyclic AMP) (10(-6) molar) to enhance the growth inhibitory effect: the cell replication ceased completely within 2 days after treatment. The growth arrest accompanied a change in cell morphology and was preceded by increases in the cellular concentration of cyclic AMP, adenylate cyclase, and type II cyclic AMP-dependent protein kinase activities as well as a decrease of estrogen binding activity. The results suggest that growth of human breast cancer cells is subject to cyclic AMP-mediated regulation and that arginine may play a specific role in this process.


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Extracellular protein kinase A as a cancer biomarker: Its expression by tumor cells and reversal by a myristate-lacking Calpha and RIIbeta subunit overexpression.
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Expression of Q227L-Galpha s in MCF-7 human breast cancer cells inhibits tumorigenesis.
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