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Science 25 September 1981:
Vol. 213. no. 4515, pp. 1529 - 1531
DOI: 10.1126/science.6269180
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Articles

Science, Vol 213, Issue 4515, 1529-1531
Copyright © 1981 by American Association for the Advancement of Science

articles

Lithium increases serotonin release and decreases serotonin receptors in the hippocampus

SL Treiser, CS Cascio, TL O'Donohue, NB Thoa, DM Jacobowitz, and KJ Kellar

The effects of long-term lithium administration on pre- and postsynaptic processes involved in serotonergic neurotransmission were measured in rat hippocampus and cerebral cortex. Long-term lithium administration increased both basal and potassium chloride-stimulated release of endogenous serotonin from the hippocampus but not from the cortex. Serotonergic receptor binding was reduced in the hippocampus but not in the cortex. These results suggest a mechanism by which lithium may stabilize serotonin neurotransmission.


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