Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 25 September 1981:
Vol. 213. no. 4515, pp. 1527 - 1529
DOI: 10.1126/science.7280675
Prev | Table of Contents | Next

Articles

Science, Vol 213, Issue 4515, 1527-1529
Copyright © 1981 by American Association for the Advancement of Science

articles

Myelinated nociceptive afferents account for the hyperalgesia that follows a burn to the hand

RA Meyer and JN Campbell

Monkeys and human subjects were exposed to a series of thermal stimuli before and after a 53 degrees C, 30-second burn to the glabrous skin of the hand. The responses of C- and A-fiber nociceptive afferents in the monkeys and subjective responses by the humans were compared. The burn resulted in increased sensitivity of the A fibers, decreased sensitivity of the C fibers, and increased pain sensibility (hyperalgesia) in the human subjects.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cannabinoid Modulation of Cutaneous A{delta} Nociceptors During Inflammation.
C. Potenzieri, T. S. Brink, C. Pacharinsak, and D. A. Simone (2008)
J Neurophysiol 100, 2794-2806
   Abstract »    Full Text »    PDF »
Psychophysical and Physiological Evidence for Parallel Afferent Pathways Mediating the Sensation of Itch.
L. M. Johanek, R. A. Meyer, T. Hartke, J. G. Hobelmann, D. N. Maine, R. H. LaMotte, and M. Ringkamp (2007)
J. Neurosci. 27, 7490-7497
   Abstract »    Full Text »    PDF »
Heat Sensitization in Skin and Muscle Nociceptors Expressing Distinct Combinations of TRPV1 and TRPV2 Protein.
K. K. Rau, N. Jiang, R. D. Johnson, and B. Y. Cooper (2007)
J Neurophysiol 97, 2651-2662
   Abstract »    Full Text »    PDF »
Transient receptor potential ion channels as participants in thermosensation and thermoregulation.
M. J. Caterina (2007)
Am J Physiol Regulatory Integrative Comp Physiol 292, R64-R76
   Abstract »    Full Text »    PDF »
Morphine Directly Inhibits Nociceptors in Inflamed Skin.
H. N. Wenk, J.-D. Brederson, and C. N. Honda (2006)
J Neurophysiol 95, 2083-2097
   Abstract »    Full Text »    PDF »
Agonist Recognition Sites in the Cytosolic Tails of Vanilloid Receptor 1.
J. Jung, S.-Y. Lee, S. W. Hwang, H. Cho, J. Shin, Y.-S. Kang, S. Kim, and U. Oh (2002)
J. Biol. Chem. 277, 44448-44454
   Abstract »    Full Text »    PDF »
Characterization of Adelta - and C-Fibers Innervating the Plantar Rat Hindpaw One Day After an Incision.
E. M. Pogatzki, G. F. Gebhart, and T. J. Brennan (2002)
J Neurophysiol 87, 721-731
   Abstract »    Full Text »    PDF »
Sensory experiences in humans and single-unit activity in cats evoked by polymodal stimulation of the cornea.
M C. Acosta, C. Belmonte, and J. Gallar (2001)
J. Physiol. 534, 511-525
   Abstract »    Full Text »    PDF »
Inactivation and tachyphylaxis of heat-evoked inward currents in nociceptive primary sensory neurones of rats.
S. Schwarz, W. Greffrath, D. Busselberg, and R.-D. Treede (2000)
J. Physiol. 528, 539-549
   Abstract »    Full Text »    PDF »
Trigeminohypothalamic and Reticulohypothalamic Tract Neurons in the Upper Cervical Spinal Cord and Caudal Medulla of the Rat.
A. Malick, R. M. Strassman, and R. Burstein (2000)
J Neurophysiol 84, 2078-2112
   Abstract »    Full Text »    PDF »
Response Properties and Organization of Nociceptive Neurons in Area 1 of Monkey Primary Somatosensory Cortex.
D. R. Kenshalo, K. Iwata, M. Sholas, and D. A. Thomas (2000)
J Neurophysiol 84, 719-729
   Abstract »    Full Text »    PDF »
The development of cutaneous allodynia during a migraine attack Clinical evidence for the sequential recruitment of spinal and supraspinal nociceptive neurons in migraine.
R. Burstein, M. F. Cutrer, and D. Yarnitsky (2000)
Brain 123, 1703-1709
   Abstract »    Full Text »    PDF »
Response of Cutaneous A- and C-Fiber Nociceptors in the Monkey to Controlled-Force Stimuli.
R. M. Slugg, R. A. Meyer, and J. N. Campbell (2000)
J Neurophysiol 83, 2179-2191
   Abstract »    Full Text »    PDF »
Mechanical and Heat Sensitization of Cutaneous Nociceptors After Peripheral Inflammation in The Rat.
D. Andrew and J. D. Greenspan (1999)
J Neurophysiol 82, 2649-2656
   Abstract »    Full Text »    PDF »
Craniofacial Pain and Motor Function: Pathogenesis, Clinical Correlates, and Implications.
C.S. Stohler (1999)
Critical Reviews in Oral Biology & Medicine 10, 504-518
   Abstract »    Full Text »    PDF »
Myelinated Mechanically Insensitive Afferents From Monkey Hairy Skin: Heat-Response Properties.
R.-D. Treede, R. A. Meyer, and J. N. Campbell (1998)
J Neurophysiol 80, 1082-1093
   Abstract »    Full Text »    PDF »
The Low-Affinity Neurotrophin Receptor p75 Regulates the Function But Not the Selective Survival of Specific Subpopulations of Sensory Neurons.
C. L. Stucky and M. Koltzenburg (1997)
J. Neurosci. 17, 4398-4405
   Abstract »    Full Text »    PDF »
Coupling of action potential activity between unmyelinated fibers in the peripheral nerve of monkey.
R. Meyer, S. Raja, and J. Campbell (1985)
Science 227, 184-187
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)