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Science 25 September 1981:
Vol. 213. no. 4515, pp. 1503 - 1505
DOI: 10.1126/science.7280669
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Articles

Science, Vol 213, Issue 4515, 1503-1505
Copyright © 1981 by American Association for the Advancement of Science

articles

Progesterone regulation of the occupied form of nuclear estrogen receptor

WC Okulicz, RW Evans, and WW Leavitt

Total concentrations of estrogen receptor in the uterine nuclear fraction are reduced rapidly after progesterone treatment of the proestrous hamster. Progesterone acts selectively on the occupied form of the nuclear estrogen receptor, with no effect on the concentration of an unoccupied form. This observation indicates that progesterone modulates the action of estrogen by controlling nuclear retention of the estrogen-receptor complex.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Rationale for Estrogen With Interrupted Progestin as a New Low-Dose Hormonal Replacement Therapy.
R. F. Casper, N. J. MacLusky, C. Vanin, and T. J. Brown (1996)
Reproductive Sciences 3, 225-234
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Science. ISSN 0036-8075 (print), 1095-9203 (online)