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Science 18 September 1981:
Vol. 213. no. 4514, pp. 1397 - 1400
DOI: 10.1126/science.6973822
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Articles

Science, Vol 213, Issue 4514, 1397-1400
Copyright © 1981 by American Association for the Advancement of Science

articles

Suppression of immunity by stress: effect of a graded series of stressors on lymphocyte stimulation in the rat

SE Keller, JM Weiss, SJ Schleifer, NE Miller, and M Stein

In rats a graded series of stressors produced progressively greater suppression of lymphocyte function, as measured by the number of circulating lymphocytes and by phytohemagglutinin stimulation of lymphocytes in whole blood and isolated cultures. This evidence suggests that stress suppresses immunity in proportion to the intensity of the stressor.


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