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Science 11 September 1981:
Vol. 213. no. 4513, pp. 1257 - 1259
DOI: 10.1126/science.7268433
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Articles

Science, Vol 213, Issue 4513, 1257-1259
Copyright © 1981 by American Association for the Advancement of Science

articles

Toxic injury to isolated hepatocytes is not dependent on extracellular calcium

MT Smith, H Thor, and S Orrenius

Freshly isolated hepatocytes from phenobarbital-treated rats were incubated in the presence or absence of extracellular calcium with three differently acting liver cell toxins, namely carbon tetrachloride, bromobenzene, and ethylmethanesulfonate. In the absence of extracellular calcium these three compounds were far more toxic to the cells than in its presence. This result is inconsistent with the hypothesis that an influx of extracellular calcium is required as the final step in toxic liver cell injury.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Drug-Induced Hepatotoxicity.
N. KAPLOWITZ, T. Y. AW, F. R. SIMON, and A. STOLZ (1986)
Ann Intern Med 104, 826-839
   Abstract »    PDF »
Acute Pancreatitis.
M. C. GEOKAS, H. A. BALTAXE, P. A. BANKS, J. SILVA Jr., and C. F. FREY (1985)
Ann Intern Med 103, 86-100
   Abstract »    PDF »
Vitamin E reversal of the effect of extracellular calcium on chemically induced toxicity in hepatocytes.
M. Fariss, G. Pascoe, and D. Reed (1985)
Science 227, 751-754
   Abstract »    PDF »
Bleb formation in hepatocytes during drug metabolism is caused by disturbances in thiol and calcium ion homeostasis.
S. Jewell, G Bellomo, H Thor, S Orrenius, and M Smith (1982)
Science 217, 1257-1259
   Abstract »    PDF »
Role of calcium in trypanocidal drug action.
A. Clarkson Jr and B. Amole (1982)
Science 216, 1321-1323
   Abstract »    PDF »


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