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Science 11 September 1981:
Vol. 213. no. 4513, pp. 1212 - 1219
DOI: 10.1126/science.7268428
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Articles

Science, Vol 213, Issue 4513, 1212-1219
Copyright © 1981 by American Association for the Advancement of Science

articles

The golgi apparatus: two organelles in tandem

JE Rothman

The Golgi apparatus consists of distinct cis and trans compartments that may act sequentially to refine the protein export of the endoplasmic reticulum by removing escaped endoplasmic reticulum proteins. Refinement may be a multistage process akin to fractional distillation; the stack of cisternae comprising the cis Golgi may be the plates in this distillation tower. The trans Golgi, consisting of the last one or two cisternae, may be the receiver that collects from the cis Golgi only its most refined fraction for later distribution to specific locations throughout the cell.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Countercurrent Distribution of Two Distinct SNARE Complexes Mediating Transport within the Golgi Stack.
A. Volchuk, M. Ravazzola, A. Perrelet, W. S. Eng, M. Di Liberto, O. Varlamov, M. Fukasawa, T. Engel, T. H. Sollner, J. E. Rothman, et al. (2004)
Mol. Biol. Cell 15, 1506-1518
   Abstract »    Full Text »    PDF »
Inaugural Article: Organellar relationships in the Golgi region of the pancreatic beta cell line, HIT-T15, visualized by high resolution electron tomography.
B. J. Marsh, D. N. Mastronarde, K. F. Buttle, K. E. Howell, and J. R. McIntosh (2001)
PNAS 98, 2399-2406
   Abstract »    Full Text »    PDF »
Vesicles on strings: Morphological evidence for processive transport within the Golgi stack.
L. Orci, A. Perrelet, and J. E. Rothman (1998)
PNAS 95, 2279-2283
   Abstract »    Full Text »    PDF »
Scattered Golgi Elements during Microtubule Disruption Are Initially Enriched in Trans-Golgi Proteins.
W. Yang and B. Storrie (1998)
Mol. Biol. Cell 9, 191-207
   Abstract »    Full Text »
ERS-24, a Mammalian v-SNARE Implicated in Vesicle Traffic between the ER and the Golgi.
I. Paek, L. Orci, M. Ravazzola, H. Erdjument-Bromage, M. Amherdt, P. Tempst, T. H. Sollner, and J. E. Rothman (1997)
J. Cell Biol. 137, 1017-1028
   Abstract »    Full Text »    PDF »
Retention and retrieval: both mechanisms cooperate to maintain calreticulin in the endoplasmic reticulum.
B Sonnichsen, J Fullekrug, P Nguyen Van, W Diekmann, D. Robinson, and G Mieskes (1994)
J. Cell Sci. 107, 2705-2717
   Abstract »    PDF »
Cholesterol and the Golgi apparatus.
M. Bretscher and S Munro (1993)
Science 261, 1280-1281
   PDF »
Stacking of Golgi cisternae in Schizosaccharomyces pombe requires intact microtubules.
K Ayscough, N. Hajibagheri, R Watson, and G Warren (1993)
J. Cell Sci. 106, 1227-1237
   Abstract »    PDF »
The trans Golgi network: sorting at the exit site of the Golgi complex.
G Griffiths and K Simons (1986)
Science 234, 438-443
   Abstract »    PDF »
Pathways of protein secretion in eukaryotes.
R. Kelly (1985)
Science 230, 25-32
   Abstract »    PDF »
The concept of self-organization in cellular architecture.
T. Misteli (2001)
J. Cell Biol. 155, 181-186
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)