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Science 4 September 1981:
Vol. 213. no. 4512, pp. 1122 - 1123
DOI: 10.1126/science.6973821
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Articles

Science, Vol 213, Issue 4512, 1122-1123
Copyright © 1981 by American Association for the Advancement of Science

articles

Somatomedin B: mitogenic activity derived from contaminant epidermal growth factor

CH Heldin, A Wasteson, L Fryklund, and B Westermark

The mitogenic effect of somatomedin B on human cultured glial cells was neutralized by the addition of antibodies to mouse epidermal growth factor. Somatomedin B contained epidermal growth factor--like activity, competing for binding to the epidermal growth factor receptor. It is concluded that contaminating epidermal growth factor may explain the entire mitogenic activity of somatomedin B.




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